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Very very drunk. also see Pissed Blitzed
The boss to a waiter: Dont put that much liquor in their drink or their be knocked for six!
by Howard Owen June 16, 2007
To be completely devastated. It comes from the highest scoring action in the sport of cricket:- where the ball exits the circle without leaving the ground.
I was knocked for six after my husband left me

My car was knocked for six after I rammed it into a wall.
by Kung-Fu Jesus April 28, 2004