When you are a fairly attractive person but you can't seem to maintain a relationship regardless of how attractive you are.
SUE: My boyfriend broke up with me. I thought we had a great relationship. I don't understand why I can't manage to stay in a good relationship.

LORI: Girl...you got Jennifer Aniston Syndrome.
by not4uboy August 21, 2010
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Not wearing a bra with your shirt or dress.
look at that skank over there
she's hot, but she's totally pulling a Jennifer Aniston
by sweaty sock sally February 22, 2012
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Award winning actress, executive producer, director, and a absolute queen
Oh look it’s SAG award winner Jennifer Aniston
by Alex’s Bitch September 23, 2020
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She is perfection. Every room she walks into she fills it with light, joy, and happiness. Her smile is everything <3
“Jennifer Aniston truly is America’s Sweetheart...”
by Annie Mclaine October 22, 2020
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A compliment one pays to his wife or girlfriend, especially as they approach a more mature age. Meaning she is as hot if not hotter than Jennifer Aniston (circa: Just Go With It bikini scene)
Husband telling his wife: "Fuck Jennifer Aniston, I'd rather sleep with you!"
by FWB4D November 21, 2022
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Jennifer Aniston means the most beautiful woman

Jennifer Aniston is an American Actress best known for F.R.I.E.N.D.S, Just Go With It, We are The Millers, The Morning Show
Yeah she's pretty but is no Jennifer Aniston
by rio2002 November 23, 2021
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Noun.

When you seem to not age at all or even age backwards. Usually by way of plastic surgery.
Rebecca: Wow! You actually look younger than the last time I saw you!

Sheryl: Well, I did get diagnosed with Jennifer Aniston Syndrome
by HorseJerky1776 January 5, 2020
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