When you are a fairly attractive person but you can't seem to maintain a relationship regardless of how attractive you are.
SUE: My boyfriend broke up with me. I thought we had a great relationship. I don't understand why I can't manage to stay in a good relationship.
LORI: Girl...you got Jennifer Aniston Syndrome.
LORI: Girl...you got Jennifer Aniston Syndrome.
by not4uboy August 21, 2010
by sweaty sock sally February 22, 2012
by Alex’s Bitch September 23, 2020
She is perfection. Every room she walks into she fills it with light, joy, and happiness. Her smile is everything <3
“Jennifer Aniston truly is America’s Sweetheart...”
by Annie Mclaine October 22, 2020
A compliment one pays to his wife or girlfriend, especially as they approach a more mature age. Meaning she is as hot if not hotter than Jennifer Aniston (circa: Just Go With It bikini scene)
by FWB4D November 21, 2022
Jennifer Aniston means the most beautiful woman
Jennifer Aniston is an American Actress best known for F.R.I.E.N.D.S, Just Go With It, We are The Millers, The Morning Show
Jennifer Aniston is an American Actress best known for F.R.I.E.N.D.S, Just Go With It, We are The Millers, The Morning Show
by rio2002 November 23, 2021
Rebecca: Wow! You actually look younger than the last time I saw you!
Sheryl: Well, I did get diagnosed with Jennifer Aniston Syndrome
Sheryl: Well, I did get diagnosed with Jennifer Aniston Syndrome
by HorseJerky1776 January 5, 2020