A major interstate highway in the central United States. It runs from Duluth, Minnesota, to Laredo, Texas, connecting the cities of Minneapolis/St. Paul, Des Moines, Kansas City, Wichita, Oklahoma City, Dallas/Ft. Worth and San Antonio. It splits into I-35W and I-35E in the Minneapolis and Dallas areas. Not a scenic interstate, but few east of the Rocky Mountains truly are.
If you drive I-35 through Minnesota en route to Duluth, northern cities, or cities in eastern Minnesota and Wisconsin on I-94, take I-35E because I-35W sucks Crosstown Commons. If you are going to Minneapolis or going to western Minnesota cities on I-94, take I-35W to I-494 up to I-394 and east into Minneapolis, or I-494 up to I-94 on the northwest corner of the metro.

Lesson: Try to avoid I-35W if at all possible.
by The Volkswagen Beatle December 31, 2005
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A 319 mile long freeway in New York. It runs from Champlain (candadian border)down to the big city (NYC). It has an intersection with Interstate 90 in Guilderland, and has 7 spur routes (787,287,387 etc;).

In other words, a long ass highway.
So when you're dead and gone......
by Blahb March 11, 2005
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The 2d longest North-South Interstate Highway in the United States, it runs from the Canadian Border in Maine to Miami, FL. The highway connects critical cities such as Boston, New York, Baltimore, Washington DC, Richmond VA.
I was driving on Interstate 95 when those new Chicken McNuggets from McDonald's hit me and i had to drop a shit on the side of the highway.
by McDizzle March 29, 2004
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Possibly the worst freeway in the Twin Cities except maybe Crosstown 62. It certainly has the two most dangerous interchanges in the metro, filled with weaving and tightly spaced interchanges, at I-35E and also at a huge interchange with MN 51 and US 10. Also has a crappy interchange at I-35W and and a useless dual-signage route with I-94, which is its parent route anyway.
"The fastest way to Minneapolis from here is I-694 to I-35W."

"Let's take Highway 100 or 169 to I-394 instead, because I don't want to get killed."

"Agreed."
by The Volkswagen Beatle June 21, 2005
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The most rural Interstate (except maybe I-8). Between San Antonio and Los Angeles, I-10 is either in a large town or in absolute nothingness. It has an intersection with I-20 in the middle of nowhere in Texas, 130 miles from El Paso and 450 miles from San Antonio.

Of somewhat interest is "The Thing". I myself do not know what that is but it is located near Texas Canyon, Arizona, on I-10.

I-10 passes through these major cities:

Los Angeles, Phoenix, Tucson, El Paso (even though nobody would put it on this list), San Antonio, Houston, New Orleans, and Jacksonville.
"Wanna go see The Thing?"

"Where's that?"

"Nowhere, Arizona, on I-10"
by The Volkswagen Beatle June 22, 2005
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Sticking a toy car into a girl's vagina
After raiding his Hot Wheel collection he gave his sister a California Interstate
by J-Beize May 1, 2009
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When a girl does not take a shower and especially does not wash her vagina. She then procedes to sit on the face of the male and moves in all directions making the nose of the male ride up even farther into the crouch of the female. To simulate like riding a bicycle, when the bike seat is the males face.
"Yeah my girlfriend gave me an Interstate Bicycle last night and i almost threw up"

Guy: I am not letting you trick me into a Interstate Bicycle again. you better wash that thing again.
Girl:FINE!
by Sam Rowley April 16, 2008
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