"That is off the hook for real" would be the literal meaning of the phrase. It means that something is extremely novel and interesting, and that you're dumb enough to think you sound cool adding "izzle" to the end of your words.
Dude A: Hey dude, have you seen Frank's new car?
Dude B: Why yes I have. That tizzle off the hizzle foshizzle.
Dude A: WTF?!?!?!
by Rosekelly June 22, 2008
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It's off the hook for sure, dog! (literal translation)

Means: It's great stuff, my friend!
In the Girls Gone Wild commercial, Snoop says, wrt his "Doggy Style" GGW video:
It's off the hizzle fo shizzle, dizzle!
by Adrian March 13, 2003
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Wizzle=What
Da=The
Hizzle=Hell
Be=is or be
dat=that
shizzle=shit

Wizzle+Da+Hizzle+Be+dat+Shizzle= What the hell is up with that shit?
Person: Hey, look at that.

Another Person: Wizzle da hizzle be dat shizzle???
by Walt January 31, 2004
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i am not needing a bj right now. come back later u nigga.
Hey billy. Jimmy says "Bounce ur shizzle off his hizzle my nizzle!" he wants u latta.
by ur mom May 6, 2003
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