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1.
To fight someone 1 on 1 with no one else getting involved
Yo you got beef? Lets head up
by Al-B April 07, 2006
88 52
 
2.
Something said to someone meaning that they should not be ashamed of anything or that they shouldn't be sad. It means that they should not stare at the ground in despair but rather pick their head up and stand tall.
Jim: John, why are you so sad?
John: I fucked Sally Parker and she's pregnant.
Jim: Sally Parker?! She's hot as fuck. Head up.

Jim: We just lost the state championship. I am so sad.
John: You guys are a great team and came a long way. Head up.
by John Fuckerino December 09, 2013
6 1
 
3.
When someone is "head up" they are angry or frustrated. It is mostly a Southern saying. You can hear it being said in The Rescuers film and other movies with Southern people.
When Gramps gets head up, his nose gets plumb outta joint
by Juderunner February 22, 2011
17 16
 
4.
to evacuate, to leave somewhere with extreme quickness
'Yo man i heard Rico's coming, dude you better head up real quick'
by crookedcityinthetrees10 October 13, 2008
9 16