Top Definition
To cause one to not be able to move, walk, or function. To immobilize someone, to make someone powerless. (taken from the literal practice of cutting with a knife an animal's or person's hamstring muscle) past tense - hamstrung
The lack of investors will hamstring my efforts to move the project forward.

I was hamstrung by the flu prior to the marathon.
by irzapper August 14, 2007
A crude term for "penis".
Girl: I will karate chop you right in the hamstring!
Guy: Jesus, that's a crude term for a penis.
Girl: Omg lol i don't even know what to do with you.
by Dekrepit90 June 09, 2016
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