Top Definition
a term used to describe your most chilling of all your boys. Your "guyzer" is only used to describe a select few of your friends that you truely trust, appreciate, back, and want to associate youself with.
"I said yooo guyzer, what are you saying tonight? You wanna chill down at the spot?"

"How are you guyzer, your looking good today ;)"
by Katzilla January 16, 2006

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