The process of using heroin and methamphetemine (aka meth, crystal meth, ice, etc) simultaneously.

Goofballing is achieved by mixing heroin and meth together in a single rig (syringe), and then slamming (injecting) the mixture into a vein.

Procedurally, goofballing is nearly identical to speedballing, except a goofball mixes heroin & meth, where a speedball mixes heroin and cocaine or crack cocaine.

At the most basic & simplistic level, I explain goofballing as “Heroin AM.”

After doing a goofball one will feel all the euphoric, “feel good” effects of the heroin, a “downer” but none of the usual feelings of drowsiness and tendency to nod that goes along with it. Instead, one will feel a burst of energy & creativity, as well as the ability to stay awake for many days in a row (like it or not), from the addition of methamphetemine, an “upper.”

It makes one feel on top of the world, but beware: add too much meth and instead of feeling on top of the world, it can feel like you’re floating away from the earth, a gnarly feeling to be sure, but also highly disconcerting, to put it lightly!
Goofballing kept us dancing all night long, but despite wearing stilettos, my feet didn’t hurt a bit!
by SnowWhyte June 15, 2019
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A term of endearment between online friends, similar to "buddy", "bro", etc. Tends to be used when one friend does something silly or funny.
Used mainly in America by those unfamiliar with the derogative form of the word.

Also used: goof, goofball, goofy
"You're such a goofball :P"
"You're so goofy"
by BohemianGoof February 10, 2012
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When you mix heroin and crystal meth together in a shot. West coast slang.
That goofball sent me to the moon for hours.
by dabqueen710 June 4, 2016
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Formerly and through the late 1980s anf 1990s, slang for barbiturates. Later expanded in common vernacular to include benzodiazepines (such as Xanax and Valium).

Commonly used today to describe the recreational combination and use of heroin and methamphetamine via IV injection.
When cooking up a hit of dope, "I got a couple points of shards, too; you wanna slam a goofball?"
by Fuckingspiders October 3, 2016
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Someone who is silly or stupid. Also looks silly or stupid.

Opposite of a chill bro.

People generally laugh at them than with them.
A: Do you know Declan?
B: Nah, I don't.
A: You know, the massive goofball?
B: Oh, yep! He's the king of goofballs.
by Double Denim Ranga August 2, 2010
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west coast slang for crystal meth and heroin in the same intravenous shot. it is not to be confused with speedball (cocaine and heroin)
jay: I got clear and black you wanna goofball?
jesse: im on my way let’s get goofy.
by amphboy January 18, 2019
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