The process of using heroin and methamphetemine (aka meth, crystal meth, ice, etc) simultaneously.

Goofballing is achieved by mixing heroin and meth together in a single rig (syringe), and then slamming (injecting) the mixture into a vein.

Procedurally, goofballing is nearly identical to speedballing, except a goofball mixes heroin & meth, where a speedball mixes heroin and cocaine or crack cocaine.

At the most basic & simplistic level, I explain goofballing as “Heroin AM.”

After doing a goofball one will feel all the euphoric, “feel good” effects of the heroin, a “downer” but none of the usual feelings of drowsiness and tendency to nod that goes along with it. Instead, one will feel a burst of energy & creativity, as well as the ability to stay awake for many days in a row (like it or not), from the addition of methamphetemine, an “upper.”

It makes one feel on top of the world, but beware: add too much meth and instead of feeling on top of the world, it can feel like you’re floating away from the earth, a gnarly feeling to be sure, but also highly disconcerting, to put it lightly!
Goofballing kept us dancing all night long, but despite wearing stilettos, my feet didn’t hurt a bit!
by SnowWhyte June 15, 2019
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a drug that makes u goof off
goofballs are the best drugs ever
by nunes May 31, 2006
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a goofball is a word to describe an Amelia, not just any Amelia
THE goofball amelia

she is the definition of a goofball

always in a silly goofy mood 🤪
(Susan) oh look at her what a goofball

(Will) no shit Sherlock it’s Amelia
by Susan.mills February 1, 2022
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Alvin Fayette, Number 1 Goofball
Ed Stapley-Brown, Number 2 Goofball
Matt Isanook, Number 3 Goofball
by Bratley May 22, 2003
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Injecting cocaine intraveniously
He was goofballing that night, which explained his talkative behavior and the injection marks on his arms.
by ask123 March 4, 2008
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