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1.
Gang Busters was a famous radio program that was first heard in 1936 and aired until 1957. The sound effects of police sirens, tommyguns, and screeching tires that opened the show were dramatic and exciting -- this inspired the expression 'coming on like gangbusters'.
Usage has opened up to describe things that are not just exciting, but successful, intense, and many other adjectives, and many drop the 'coming on like' prefix. I think we should be more careful about how we use it, and keep it true to its origin -- something that starts with much excitement and drama is 'coming on like gangbusters'.
The rainstorm late last night came on like gangbusters!
by M. Warrener January 14, 2008
 
2.
Also used in conjunction with "like", to create "like gangbusters". This phrase can be used to describe something energetic or intense.
"Its raining like gangbusters"
"Check out my gangbusters new CD"
by riloman April 15, 2004
 
3.
most commonly used in conjunction with "like" to describe something that is extremely effective
Wow, this fleshlight works like gangbusters!
by atom June 07, 2006
 
4.
A person who gangbusts.
Don't play like a bunch of gangbusters!

Carlee, you're such a gangbuster.
by TheGangbustah007 August 31, 2010
 
5.
a sexual advance made by someone in an atttempt to turn on another person
oh feel my hair, it's so soft. I know this gangbuster revs your engine.
by Jack Baeur January 31, 2006
 
6.
used to describe an action displaying a complete lack of subtlety
"When John saw the bank being robbed, he just charged in all gangbusters."
by Cole Worley March 31, 2007
 
7.
gangbusters ;adjective. When used to describe people it infers the person is highly attractive. When used to describe an object it means it is highly desirable/cool
Aaron: Oh wow that chick is so gangbusters
Bob: Yeah thats Alyssa
Aaron: wow.... gangbusters...
by Azarules February 26, 2010