It's usually used when you are surprised to learn something. Other uses are to add how serious you are being about something. The last and most obscure usage is to explain the status of a couple. They are "For Realsies" if they are officially dating.
An easy and cool response to many typical everyday interjections that requires no preparation. Also can be used as a quick response to agree to awesomeness in general or just plain shittyness of a situation at work or in personal life.
Jerry says, "So glad I work for this company - they really take care of you, but all this work is making me lose time with my friends" Sally says to Jerry, "For-Reals. Shoot...I have no life now and I think my boyfriend is cheating on me.