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1.
Underground surrogate word for "okay". Stems from the 20s and 30s as a positive term for law enforcement agencies cracking down on organized crime and alcohol.
"Is that all fifty?"

-OR-

"Are you fifty?"

-OR-

"She's fifty."
by ZanzibarBreeze December 29, 2009
 
2.
Fifty caliber.. a round of ammunition the bullet of which is a half inch (12.7mm) in diameter.

A common .50 cal round is the .50 BMG (Browning Machine Gun), the round which is (unsurprisingly) designed for the Browning .50 caliber machine gun.

The BMG itself is the large belt-fed machine gun known as a Ma Deuce. It was invented at the time of WWII but has remained in manufacture to this day because it is a very sound and effective design which it would be kinda hard to really improve on.

Now however there are a lot of other guns, including shoulder-fired rifles and even a single-shot pistol, firing the BMG round.

Fifty can also refer to the weapon used to fire .50 caliber ammuntion.
The Huey door gunner grinned and opened up on the Viet geurillas with his fifty.
by Dirge October 06, 2004
 
3.
the cops
holy shit, stash it, theres the fifty
by shannon June 23, 2004
 
4.
Every woman's idea of the perfect guy that shares not only a connection but also the same 'kinky' and sexual attraction.
"He knows exactly what I like, he's my fifty."
by hopeless07 September 13, 2012
 
5.
Further shortening of FFD (acronym for Fat Fucking Disgrace).
"Look at Kid Fifty over there" (indicating a fat black kid with man boobs from eating too much candy)

"Wow. Check out the comment from Shirtless Doug Fifty!" (indicating a comment left on a busty girl's Myspace page by a fat, shirtless man from Ohio that contains both numerous references to sensuality, and numerous spelling and grammatical errors.)
by Dean PGH June 10, 2008
 
6.
Some good ass weed; fifty for a 8th
Whatz up heard you had some fifties
by A-Hood February 07, 2007
 
7.
another name for mersh... or the weed one step above shwag... give you a shitty hi that only good if your just doing it to get stoned.
Colman and I bought that fifty at wallgreens from our usual.
by Dave-izzle September 27, 2005