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2.
To do the worst thing possible given a certain situation.
John:You let Mike borrow your car? Are you crazy?
Joe:He said it was an emergency. Relax. As long as he doesn't do the doo doo he'll be fine.

It is assumed that Mike drives recklessly. He would do the doo doo if he drove drunk or was speeding.
by 2014_chiguy April 04, 2007
 
1.
1. To defecate
2. To sodomise someone whose rectum is not empty
1. She's been in the toilet 10 minutes - I think she's doing the doo doo
2. I don't care if she's not ready - next time she bends over I'm gonna jump on her and do the doo doo
by Noxema-Tapioca May 02, 2009