Tweedle Duffer

Someone who goes into the jungle gets bitten by a tick or denge bug and catches a 5 day fever AKA jungle fever

I held on to the antibiotics incase I met sombody who would be such a tweedle duffer as to run though the jungle with no bug spray on.

Tweedle Duffer by DemonWeapon April 14, 2017

The Duffy Effect 

When someone befriends the handicapped solely based on the fact that they have a disability. The Duffy Effect involves a person who does not take into consideration that their new handicapped friend may actually be undeserving of friendship.

Katie: "I've always been nice to Ryan, but now he asked me to prom!"

Drew: "The handicapped kid? This is a textbook example of The Duffy Effect! That kid is an asshole anyway."

The Duffy Effect by Lafferty Daniel October 2, 2008

duffle ass

A white girl with An ass so wide and out of shape that is resembles a duffle bag full of dirty laundry

Shirley over at Applebee’s is such a bitch yo!!
I wanna break my foot off in her duffle ass!!

duffle ass by Hasbeenoncewas May 29, 2018

Duffifie 

To lay a bottle on its side-after drinking its contents-to collect the few remaining drops, which can then be poured (or dribbled) into a glass. Also, to "make the bottle confess"

From Scottish (see John Jamieson's Etymological Scottish Dictionary, 1808). Now obsolete.

Grandpa Tony is always sure to duffifie after finishing his wine, proclaiming, "If it's enough to take a pill with, it's enough for me."

Duffifie by Huisman January 10, 2011

duff man 

A fictional spokesman for the beer company:
"Duff".
He represents all that is malty
and alcholic.
Tends to do alot of thrusting
to the song "Oh yeah" by Yello.

The simpsons.
"Duff man is thrusting in the direction
of the problem!"
"Duff man can never die,
only the actors who play him!"

duff man by Phoebe April 6, 2004

DUFF Man 

The wingman who takes one for the team and talks to the Designated Ugly Fat Friend (DUFF). So the player has the opportunity to pick up the babe.

James was a great DUFF Man last night, otherwise I would have never gotten that babe home.

DUFF Man by Frankie B Govan October 21, 2015

Hillary Duff Would Not Approve

Any time you use the word "gay" to describe something you don't like. It is based on the tv edumercials staring Hillary Duff. The commercials are intended to stop this use of the word "gay" which is in itself a good cause, but the commercials are so ridiculous that they have become a joke on their own.

guy 1: Hey did you hear that Mr. Garcia is collecting our current events TODAY??? That's so gay!

guy 2: Hey man, Hillary Duff Would Not Approve

Hillary Duff Would Not Approve by Changus Kahn July 11, 2009