Top Definition
to take a big shit; the phrase is used most appropriately when prairie doggin, that is, when the rectum has reached critical shit capacity and the pressing need to shit dominates.
Dude, I have to go right fuckin now. I gotta deuce it up!
by tuberculosis October 13, 2007
Gotta take a shit or got to poop

She should have deuce it up before I ATMed her.
by Ajpatta May 03, 2008

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