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1.
being in an agitated or restless state; also, having the need to be outside in open space (see cabin fever).
"Man I'm like crawling the walls here! I need to get out and bust it up somewhere!"

"Hey babe, let's go for a walk. I don't know about you, but if I stay too much longer inside this house I'll be crawling the walls soon!"
by Hipster April 13, 2008
 
2.
When someone is so horny that they really need a good fuck. Mainly used by females.
After I broke my vibrator, I've been crawling the walls every night waiting for my man to get home.
by Fred Riahi May 21, 2006