I. Literally, translates to what has sometimes been termed the most obscene word in the English language "cunt"...
II. Usually used as a passionate, emphatic expletive (see fuck!, shit!, damn!, etc...) Significantly more vulgar than "mierda" (shit).
Transl.: FUCK man, she knows!
Also used in the Philippines as a semi-derogatory term for people who seem to be high-class and vain or conscious about their social status and speak in Taglish or broken-Tagalog mixed with English.