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Carbuncle references a random text box seen in Game Grumps episode number two of Sonic Shuffle saying “The Carbuncle ate itself.” This notification was completely unrelated to what was happening in the game and only interrupted the conversation Danny and Arin were having. The phrase has since become a running joke and reference within the fanbase.

Therefore, a “carbuncle” is a person who interrupts or contributes nothing of value, interest, or importance to a conversation.
Kristen, could you quit being a carbuncle?”

“Jax is such a carbuncle.”
carbuncle by Scha-wangus October 23, 2020

Carbunkle 

a big nasty festered pimple on ones ass
Hey bitch you need to pop that carbunkle if you want me to hit it from behind.
Carbunkle by Adam Baker October 23, 2005
The act of when a homosapian has digested said amounts of nourishments and needs to unpleasantly/forcefully relieve him or herself via the anal cavity.

Generally the creation of a carbuncle occurs when the stomach is aided by numerous amounts of alcoholic beverages, forcing the conclusion to be highly stagnant and unpleasant to pass.
Ohhhh man, I've just taken an hour long carbuncle. The glossy cushiony paper which I used to wipe away my sins where also conveyed in a rouge coloured liquid.

::2 hours later a friend turns up::

Friend :: Fuck me !!!! It's smells like chernobly in here !!!

Me :: Nah it's just the carbuncle I pushed out 2 hours ago

Friend :: Oh..... Fuck.....Well that's what I came over to do :/ I even bought you pack of toilet roll
Carbuncle by Carbuncaru December 7, 2015

Carbunkles 

Little chunks of debris, usually found around or near the butthole, caught in the hair. Comprised of fecal matter, toliet paper, lint etc.

A side effect of improper hygiene.
Cheap toliet paper will result in Carbunkles.

"She would've tossed my salad, if it weren't for these darn curbunkles!"
Carbunkles by Neck February 28, 2008
A small white corral growth on the sphincter.
The proctologist cautiously removed Andre's vicious carbuncle.
Carbuncle by Drgonzo November 18, 2003

monstrous carbuncle 

A hideous waste of public money, often on a meaningless edifice of British national pride, probably built by a German contractor.

Comedy Pyramid
That new German-built monument of British pride is a monstrous carbuncle...
monstrous carbuncle by TheIan October 22, 2003