Reaching the pinnacle of creative expression in one's chosen endeavor. Sort of like how we identify Neo in The Matrix.
Dan was so inspired to paint something that he blasted off on the canvas with every idea that came to mind.

Mike was so desperate to get on the other side of the river that he had to blast off in one magnificent leap.
by Balfdor October 11, 2006
Do to coke / get high.
Do you wanna blast off this weekend?
by Thomas V May 02, 2006
Having to take a mighty shit in someone else's toilet in there house, and hoping they don't smell it before you leave.
"After that cup of coffee, I need to blast off in Danya's shitter!"
by Webster March 31, 2003

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