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1.
someone who who systematically looks for ways to do dispicabledeeds. One who is affected with a personality disorder marked by antisocial behavior manifested in aggressive, perverted, criminal, or amoral behavior without empathy or remorse.
my coworker is a real assholiopath he always looks for ways to throw people under the bus.
by tonytiffandshawnfromboston June 11, 2005
 
2.
one who seeks to pervert, subvert, supervert, disrupt or destroy whatever one is a part of by telling half truths, inflaming rumors or simply considering one to be smarter than everyone else involved
He ruined the party plans with all his behind the scenes manipulations, but he couldn't help it, he's an assholiopath.
by Phil McCrakken December 30, 2008