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The shortest form of speaking 'truth to power' that exists. Useful for when long-winded replies are not possible and because 'dissent is the highest form of patriotism'.
Obama: Lie, lie, lie...

Joe Wilson: You lie!
by Gaspipe September 10, 2009
Is a valid response to the person who made a statement that is an obvious lie.
Obama: There are also those who claim that our reform efforts would insure illegal immigrants. This too is false - the reforms I'm proposing would not apply to those who are here illegally.

Joe Wilson: You lie!
by the_mad_rshn September 10, 2009