look up any word, like trill:
 
3.
latin slang for vagina
White guy: yo dude, did u see that girl?

latin guy: si vato, tenia una mini skirt y se le miraba todo el yofo!

White guy: que?! O.o

latin guy: la Pussy guey!
by Torched Up: JoJo ThunderBoltz April 08, 2010
 
1.
You only fuck once
E: OMG, that wedding was so fun! I'm so happy for them.
J: Yeah, but I totally heard the bride and groom YOFO'ed... Poor girl.
E: Oh man, no YOFO. Never YOFO!
by Paperscissorsrockme September 12, 2013
 
2.
You only flunk once...
You can and will only flunk photography once.. YOFO
by yeeaaahhbuddy June 01, 2012