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1.
WYO
An abbreviation commonly known as ' What You On ? '

Its used it just like the phrases ' Fuck You Mean ' or ' What You Talkin' Bout ? '
- " I saw you and Tammy kissing yesterday "

- " WYO ? We broke up last week . "
by NiggaWhisperer May 31, 2013
 
2.
wyo
An abbreviation for Wyomissing, Pennsylvania

Wyomissing is rich prep town that has lots of pot, too many fat cops, and not enough snow days. This scenically beautiful town borders the city of Reading, PA, full of low class thugs and drug dealers. Wyomissing and Reading are like completely different worlds. All you have to do is cross the bridge out of West Wyo/Reading, and you're in the hood.

Anyway, pretty much all of the people that live in wyo are rich and snobby. The funny thing is that that more then half of them try to come off as "gansta" or "poor". Everyone knows they're worth millions, but they try to deny it. They act all thug until they're in front of someone who counts, and then they're the rich nancy boys we all know they are.

When the kids party, they really PARTY. Girls are known to get completely tanked laying on their front lawns every weekend while their parents are in Dubai or some shit.

Then there's the ones who take advantage of their parents and spend money like it comes out of their butt. They all look like clones of each other in their polos, uggs, designer bags, ect.

Its a really pretty, nice town where nothing ever happens thats more exciting than Mary Caroll getting her stomach pumped at Christine Loomis' party. Not even close to the real "gangsta life" as many wyo people think that they live.
i heard there's a bangin' wyo party tonight!!

SWEET!! lets go. maybe that hot rich bitch will be drunk moaning on her front lawn again!

she clearly will be. it's saturday isn't it?
by yourmomma00698 July 13, 2006
 
3.
wyo
The former abbreviation for the great state of Wyoming. Replaced by "WY" as the state abbreviation for postage, but still recognized.
"Where are you from?"
"Oh, I'm from old Wyo".
"You poor bastard."
by ActionKym May 03, 2005
 
4.
wyo
WHAT! YEAH! OK!

lil' jon the artist uses this in many of his songs
hey r u goin out tonight?
"WHAT!"
"YEAH!"
pick u up at 6
"OK!"
"OK!"
by Yummietastieari April 16, 2005