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1.
The slut in the van that all the guys took turns nailing in High School.
"That chick used to be a Van-Girl. I was the twenty-eighth guy to hit it after a football game and there were a bunch of guys still in line after me."
by Dirty Sanchez March 02, 2004
 
2.
An abnormaly large woman, a woman so enormous that she is bedridden for life.
Im starving, van girl cleaned out my cupboard.
by Vengefulsorrow January 11, 2009