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1.
When an average looking man picks up the most beautiful girl at the party, only to get her home and find that her penis is bigger than his.
Joe: Dude, did you see who Bill left with?
Dude: You mean that tranny Jill?
Joe:Jill is a tranny?
Dude: Yes, and Bill is in for a serious case of vagirony.
by tkast68 January 09, 2012
 
2.
Observation by a female comedian of a situation that is strange and funny in an unexpected way.
With her keen sense of vagirony, Sarah Silverman was able to tell a story about her nasty yellow discharge that made her endearing to an even larger number of horny men.
by DrKam September 26, 2013