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1.
UPP
Ultimate Ping Pong. UPP consists multiple games of ping pong played in a row. Time duration of UPP is at least 60 minutes. Ultimate Ping Pong usually takes place in a friend's basement or wherever a regulation ping pong table may be found. Games are played to 21 and you must win by at least 2.
Landon- Hey man want to cheel?
Maxwell- Yeah bro UPP all day.

Chib- Hey Keith what you doing?
Keith- Can't talk. UPP.
Chib- It's okay I understand.
by Pudge7 August 16, 2009
 
2.
Street way of saying, "In regards to."
"Big upps to all my boys," or, "Big upps to all my haters."
by Nick Blancato July 10, 2008
 
3.
UPP
Stands for Uncomfortable Penis Position
I need to adjust my junk, this upp is killing me.
by BiscuitAssassin June 15, 2010
 
4.
Upp
The most amazing last name. Ever. Confuses many, makes others questions.

We've heard all the jokes.
It would be hilarious if we married someone with the last name "Down," we've gotten over the list of possible first names that would suck, like the direction, U-P-P, and yes, it IS our real last name.
"You see that amazing person over there? He must be an Upp."
by ThatUppKid May 16, 2009