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1.
When your girlfriend texts your wife thinking it's you. like Bret Favre or Tiger Woods.
She just thumbled the invite.
by lyradius August 10, 2011
 
2.
To make a typo while inputting text on a hand held device such as a cell phone.
"Hey guys, gow ard yot?"

"Sorry, I mean, how are you? Whoops, looks like I thumbled!"
by HTCS July 07, 2009
 
3.
A portmanteu of thumb and stumble, works best when used with up or down to signify delight or disgust about a page using the Stumble Upon toolbar.
"dude, shit's cash, thumble up"

"ewww, no more Nailin' Palin for me, thumbled down"
by Danliv2003 November 05, 2008
 
4.
portmanteau of Thumb and Rumble, a slang word purportedly used in online gaming.

Seen in a badly researched episode of CSI, where a fat gamer is murdered
"Whenever he's bored, he just goes online. there's always someone looking to thumble"
by NanakoAC February 19, 2013