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1.
Thotties are promiscuous females, sluts.
Often like to participate in drinking and doing drugs. Most "Thotties" are often times young single mothers who live with their parents. They are typically someones "plaything" and are tooted and booted very quickly. Most men will not marry this type of female but will however spend a couple days partying with such and then move on. As a result a "Thottie" will end up single again, looking for another dude to get "Turnup" with, or they will end up with a baby.
Term made popular by the sensation from Chicago known as Chief Keef.
I ain't even playin tho

i make bitches fly like peter pan tho
That's why i just ask you
You's a alcoholic I ain't got no time for you
Is you off the molly if i book your flight is you gonna top me
Okay you got me
I don't love no thotties
-Chief Keef "Love No Thotties"
by GoalDigger September 19, 2013
 
2.
Kelsey Fasullo. The definition of a thottie, starting from the dance to the look. She a true thottie
"I love Kelsey but she's one of those Thotties!"
by Hehe3390 August 17, 2014