(A slang term used in Magic: the Gathering.)

When an opponent takes control over one of your creatures or planeswalkers, but they cannot use/activate effects because the opponents deck is built around a different colour of mana.
Player 1: "I took control of your Moorland Inquisitor with my Mind Flayer!"
Player 2: "Yes, but you can't use his ability because he is region locked."
by Mobsiboy February 3, 2022
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A technological measure to prevent you, the consumer, from enjoying content that you paid for because it's from another country. Virtually all DVD players have this built in, as well as video game consoles. In the USA , it is illegal to modify a device in such a way as to defeat the region lock. This evil invention allows hated countries (that is countries with a race that is not preferred) to get movies and games last while Aryan countries get them first, and it makes the authentic legitimate original less valuable because of the restrictions put on it.
The fact that there is a region lock on my game console reinforces my stereotype that the U.S.A. is nowhere near a free country.

A region lock is a hate crime on a chip.
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Referring to your crotch
Yes please, in or around my crotchal region will do the trick
by scobb July 22, 2008
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An album written by Tyler Joseph also known as Jesus Christ. Album written for Twenty One Pilots (TØP). Slme synonyms for Regional at Best are Dead, died, Non-existent, and Not real
Tyler Joseph: hey guys we have a new album called Regional at Best. We are very excited for you to listen to it!

Also tyler: never mind.

Fren: :(
by FootFøøps June 25, 2019
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This is the area in which your ballsack and penis live my dear Watson.
Jerry's ballsack was swollen and changing colors from being hit in his crotchular region with a baseball bat.
by UnlimitedInfinity May 28, 2009
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Hell, Infernal Damnation

Slang - Private area of the anatomy
She's going to the nether region when she leaves this earth

Slang - I had some work done in my nether region.
by Bostonian July 28, 2006
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