Top Definition
TWU
That's whats up
Man #1 - After work imma stop by your crib with a case of beer.

Man #2 - TWU (meaning - ok cool, or i agree)
by sbf64 December 10, 2009
1 more definition
TWU
Thats whats up
We are going to gig tonight.
TWU
by SlightlyCrazeE June 17, 2010

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