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1.
TPN
TPN - Toilet Power Nap
When you have been burning the mid night oil (probaly playing online poker) and you have got to the afternoon, say arounf 3pm, having eaten too much at lunch and you start to heavy eye syndrome. Then your boss comes in and is like "off to a meeting see you tomorrow" And so you decide to go for a TPN!
by Bumsalad June 21, 2005
 
2.
TPN
may also pertain to a form of feeding done on people who can't even be tube-fed because their gut doesn't work. Stands for "total parenteral nutrition" where they actually stick nutrients right into your veins.
"what happened to the guy who got stabbed at the ATM 18 times doctor?

"who knows, we just strapped him down to the bed and sedated him so he won't pull on his TPN...tell the family he's stable and recovering."