Trump Derangement Syndrome, is the unwavering adoration and devotion to a political leader, beginning with Donald Trump the namesake of the disorder, extending to other forms of leadership including presidents and rulers typically of a fascist or populist nature. While the name is meant to have pejorative connotations the actual condition is characterized primarily by behaviors found in in "cult of leader" or "cult of personality" scenarios.
"Trump is a real player, back in the day he fondled all the ladies," "I know man, but my pastor at church LOVES Trump", "TDS man, Trump said it himself, he could shoot a man on Fifth Ave in NYC and his base would not leave him, TDS, his followers are devout!"
by CrunchKote August 31, 2019
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TDS stands for Trump Derangement Syndrome. It's a disease that affects some democrats which drives them insane whenever they hear the word "Donald" or "Trump". Disliking Donald Trump for a valid reason is not TDS but going insane whenever hearing his name mentioned is.

Another symptom is trying to turn the word around to target Trump supporters.
1. Billy: Hey, what's your favorite cartoon character?
Joe: My favorite cartoon character is Donald Du-
Billy: OMG DONALD TRUMP IS SUCH A RACIST HE WANTS TO BUILD A WALL TO KEEP OUT THE MEXICANS AND HE HATES BLACK PEOPLE AND MUSLIMS

2. Billy: I'm going to define TDS on Urban Dictionary and say that Trump supporters suffer from it.
by A4775 January 1, 2021
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"Trump Dipshits". If someone is said to be "suffering from TDS", this means that the person in question is being harassed online by asshole Trump supporters.
"Yeah, looks like somebody's suffering from TDS over here."
by inkflight March 27, 2019
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a.k.a. Trump Derangement Syndrome. The inability to find fault with Trump due to the fact that you voted for him in 2016. Also see: Cognitive Dissonance and Confirmation Bias.
Mike is disconnected from reality and plans to double-down on Trump in 2020; the TDS is strong in this one.
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TDS:trump delusional syndrome

Referring to delusional trump supporters.
Trump supporter: Trump is the greatest president of all time!

Rational human: Sorry, he has TDS. Please ignore him.
by Yourmomisamom March 20, 2020
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TDS is the acronym for Trump Devotion Syndrome. It's characterized by a singular willingness to serve criminals with the surname "Trump." Secondary symptoms include the following: edema of the heart and lungs, inflammation of the internal organs, chest tightness, and difficulty forming coherent sentences.

The disease is endemic to the United States and is believed to be, in part, a consequence of the erosion of the social contract.
Many people are saying that sufferers of Trump Devotion Syndrome (TDS) have formed a cult, willing to debase themselves and betray their country to serve a criminal, loud-mouthed Yankee.
by ManyPeopleAreSaying June 6, 2020
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