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1.
A malady affecting a significant portion of the world's population wherein the afflicted will demand special treatment, conduct themselves with a ludicrous, unfounded sense of entitlement, and generally make the lives of everyone around them that much more miserable.

The danger of this disease is that the sufferers rarely, if ever, know that they have contracted it, and continue about their merry way under the assumption that EVERYONE ELSE is the problem.

This condition, if left untreated, can radically alter the carrier's demeanor, to include any of the following: a complete devolution to child-like behavior, temper tantrums, and/or fits of narcissistic rage.

When confronted with an individual suspected of harboring Special Snowflake Syndrome, one's best course of action is to run away. Further attempts at educating the carrier on the reality of their condition (e.g., quoting Tyler Durden: "You are not special. You are not a beautiful or unique snowflake. You're the same decaying organic matter as everything else.") will likely prove futile, and potentially hazardous to the informer.
-Can you believe that lady who was just in? Where the hell am I supposed to find the earrings that match this necklace that the manufacturer stopped making ten years ago?

-Hell if I know, but she definitely had Special Snowflake Syndrome.
by TinyMightyKatie March 20, 2011
 
2.
‘Special snowflake’ syndrome, is a disease in which the subject believes that because she occupies a subculture mildly different to the mainstream, she is inherently better, and above them. The subject will never state that she is better, but it is implied, as is the belief that she is rare in her qualities, despite, in reality, being an only slightly less common cliche. Subjects suffering from this syndrome have been known to make statements such as “I’m the girl who’d rather stay home reading Harry Potter than get drunk and get ‘sweet hooks’ “, and will frequently act as if she is under tremendous pressure to act like a ‘typical girl,’ not realising that ‘typical girls’ are a myth, and those she looks down upon are not what they seem.

See also: tumblr cliche, First world problems.
As soon as she picked up that digital camera and bought some vans she caught Special Snowflake Syndrome.
by TheGreatConvex May 24, 2011
 
3.
When someone, typically a teenage girl, tells lies about themselves (or blows stuff way out of proportion) on stuff such as their online profile, in order to feel special and to gain attention. Special Snowflake Syndrome is a form of attention whore. Sites such as Tumblr are heavily populated with these morons, most of whom are either social justice warriors, weeaboos, or both. Many of them claim to have "self-diagnosed PTSD" or bipolar disorder, or sometimes even claim to have been raped or abused. They will bitch at you if you call them out on their childish behavior.
I was on one of my favorite tags on Tumblr, when I stumbled upon someone with Special Snowflake Syndrome. I sent her a message telling her to stop trying to gain attention, only for her to start bitching at me for "oppressing" her. Upon further inspection of her blog, I found out that she claimed to have self-diagnosed PTSD, and that she was apparently a plantkin, with her preferred pronouns being "leaf/roseself". Her blog posts consisted of stuff like "I started cutting again!111" with pictures of her wrists with red pen marks all over them, and "a man looked at me, so that's OBVIOUSLY rape!!!11".
by Gareki September 20, 2014