Top Definition
The female version of Bros Before Hoes. The unwritten law that female friends come before the male friends.
Jeannie: Why are you not coming to the party again?
Laurie: 'Cuz I met this sweet dude the other night.
Jeannie: <shaking head sadly> Sistahs before Mistahs, girl.
by SJB March 25, 2006

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