sis

Not meaning “sister”. Commonly used to refer to a close friend or bestfriend.

“what’s up, sis”

by kaitlyn pender January 24, 2019

SiS

Suffering in Silence

Im alone now.. SiS.

by wockh☆rdt January 3, 2023

sis

1) Short for sister
2) In the song Fuck the Pain Away by Peaches, SIS seems to stand for Stay In School...

My sis went to the movies with a scumball.

"Stay in school... Cause it's the best..."

by wxynot July 13, 2005

sis

Slang for sister

Me and my sis went to the movies.

by Thunderchild March 26, 2003

SIS

Abbreviation for: "Sisters, In, Spirit". Your Best Friend or Bae. Usually used to refer to someone really close to you, someone you spend a lot of time with, like your sister.

Girl: OMG, squad on fleek!
Girl 2: yas, we look #Fabulous
Girl: Yas Sis Yas!

by ChocolateWafflez April 15, 2015

SI

Abbr. for 'stupid idiot'

As in Football Factory from 2004:
"Jog on, you si!"

by Nige Menzel May 24, 2007

Si

Yes

“Si”

by TwistyNoodles July 27, 2020