Top Definition
1) Short for sister
2) In the song Fuck the Pain Away by Peaches, SIS seems to stand for Stay In School...
My sis went to the movies with a scumball.

"Stay in school... Cause it's the best..."
by wxynot July 12, 2005
10 Words related to sis
Slang for sister
Me and my sis went to the movies.
by Thunderchild March 25, 2003
1.) A South African English expression roughly equivalent to the American "yech" and the Afrikaans expression "sies".

2.) An American term of endearment for a sister, now also used in other countries.
1.) Sis, man, you stink!

2.) Hey, sis, hey bro, how's Ma doin'?
by Xaviana December 01, 2003
SiS as in Shit Its Sunday Commonly used on sites like Facebook and Myspace
John: Aw man SiS
Kevin: Dude I know
by Kife1100 April 05, 2009
Smirk in Silence:
The act of putting on a straight face after putting someone in a spot.
Pulling someone's leg as a group where everyone acts normal in a scenario that is funny.
Used on social networks, chat rooms and least could be!
Totally loved getting on Spook's nerves acting as if I don't know him at the bar last night. Pulled a SIS.
by far_c November 02, 2009
Abbreviation for: "Sisters, In, Spirit". Your Best Friend or Bae. Usually used to refer to someone really close to you, someone you spend a lot of time with, like your sister.
Girl: OMG, squad on fleek!
Girl 2: yas, we look #Fabulous
Girl: Yas Sis Yas!
by ChocolateWafflez April 15, 2015
acronym for snicker inside - use instead of LOL when describing what one is actually doing when one chats/texts.
person a: I blacked out last night and lost my pants.
person b: SIS. You friend, are unpredictable.
by omniv0re December 25, 2011

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