To do something despicable, disgusting or unsavory.
"I'm going to Sandusky the shit out of my endless skrimp special at Red Lobster!"

"I'm so hungry...I'm definitely Sanduskying my lunch...don't look me in the eyes while I'm eating.
by Terry McTerryson November 10, 2011
This is when you rape little boys.
Hey lets go Sandusky some mother fucking kids. or. When you were a kid did you ever get Sandusky'd
by DMDS November 08, 2011

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