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1.
Referring to Greg Sanders and Sara Sidle from the popular tv crime show, CSI: Crime Scene Investigation. When you combine Sanders (Greg) and Sidle (Sara) you get Sandle. This became popular since Sara and Greg are very flirtatious towards each other.
On YouTube there always seems to be a new Sandle video.
by itsxlexyxfoo December 29, 2006
 
2.
small, angry, drunk, midget, person
he's had too many beers, he's havin a sandle
by gilly56565656565656565 August 02, 2006