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1) a reaction to a really shocking and important story.
2) a way to say "that sucks, i'm sorry" after someone has told you something truly shitteous that happened to them recently.
3) what a father replies to a son when the son asks what is that in the toilet.
1)
kid: "i smoked soo much weed and then ate a pie out of the garbage..."
kids friend: "SHIT, SON!!!!!"

2)
guy #1: "i've had such an awful day. first, my pet fish died. then my girlfriend broke up with me. and now I found out that I only have 2 days to live.
guy #2: "shit, son."

3)
little boy: "daddy, what is that brown stuff in the toilet?"
father: "shit, son."
SHIT, SON by Numba123 October 12, 2009
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Usually said in disbelief, shock, or amazment.
Shit son! I didnt know we get ALL 100 porn channels!!!
shit son by Bill Kiniry April 10, 2006

Oh Shit Son 

A more profane and direct variation of the phrase Oh Snap, often used to indicate pleasurable suprise or to express amazement towards an individual.

Usually directed towards a person.
"Oh shit Son, you really fucked up the car"

<Bobert_the_great is on a kigging spree>
"Oh shit son, you're tearing up the place"

Son of a Mother Fucking Shit Cunt Bitch 

Something you say when your very angry or upset.
person 1: Son of a mother fucking shit cunt bitch!

person 2: What?

person 1: Were out of popsicles.
a general exclamation used in any situation, good or bad
shit son, that was tight
shit son! we almost died!
shit son by Bryan=the shit April 18, 2006

oh shit son 

An exclamation useable in just about any situation to show delight, surprise, disgust, etc...
"Oh shit son, that is badass!"
oh shit son by melsie February 15, 2010

son of shit 

When someone is the absolute worst. It does not get much worse than the Son of Shit.
That guy is a real jerk. He is the son of shit.

I don't say this very often, but you are the son of shit.
son of shit by Chuck Javers November 30, 2016