Top definition
To annoy or irritate somebody. The saying refers to rubbing an animal/cats fur the wrong way, but means to piss somebody off.
1. I have to say, that president Dubya really rubs me the wrong way!
2. Those teenybopper Stinkin Park fans always rub me the wrong way
3. Sometimes I rub people the wrong way
by Nigel Tufnel February 03, 2005
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