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1.
A reply to a clever or cheeky statement.
Oh you.
by Some guy with internet June 27, 2010
 
2.
1. A comeback to any negative statement. Similar to "I know you are but what am I", but used by adults. Said loudly and in a playful manner.

2. A response to anything a person says if you're trying to annoy them.
Bro, you suck at driving!
Oh You?
by T34418L31 May 16, 2006