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1.
Winnie the Poohs equivalent to "Mother Fucking Shit"
Oh Brother, we're out of Honey.
by tastybitch69 May 31, 2012
 
2.
not happy ( something is wrong )
oh brother my taxes are up again no wineo white heads!!
by itichie_nocanpo August 10, 2006
 
3.
1. (noun) A bitch who thinks she's the shit.
"God! That girl is such an Oh Brother! Just hearing her voice makes me want to leave the room."
by OctopusSauce October 17, 2010