When upon taking a small to moderate dose of NyQuil or other OTC sleep aids which contain antihistamine as an active ingredient the ingested pharmaceutical produces undesired side affects such as jitteriness and/or increased heart rate which counter the intended result of sleep.
There is no known cure, treatment is focused on achieving sleep. Common treatments include: large quantities of liquor/cheap beer, more of said pharm, marijuana, drugs...
Man I really wanted to sleep before my flight but i had a NyQuil backfire and I was up all night with a dry ass mouth...
Yo I fuckin hate when NyQuil backfires, fuckin stresses you out the whole next day
by lostmonster March 19, 2009
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When you get out your Roomba ( obviously full battery ). Chug a full bottle of Nyquil; strip down ( obviously ) and proceed to shit on it. Next, open your apartment door and turn your Roomba on. You will then assume the sumo position and follow it to its destination. While this is going on YOU will be masturbating. The goal is to come in front of the Roomba before you pass out. If the Roomba arrives and stalls out in front of another tenants door; chances are they will let you in simply due to shock in the position you're in. Force yourself in and continue. The goal is to cum before the police arrive or you pass out.
I was trying to recover from Covid; and took a bunch of Nyquil. Ended up doing the usual Nyquil Shitsquat.

Woke up in the neighbors apartment covered in shit and cum again...guess I did the Ol' Nyquil Shitsquat....haha.
by SuckPocket July 24, 2022
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a sleep induced by severe amounts of nyquil cough syrup
one of the deepest and calming sleeps you'll find
nyquil nappers often wake up in a fog that stays for a few hours
dan: dude why are you so out of it?
jack: i had a sick nyquil nap last night, slept for like 8 hours without waking up
craig: oh yeah me too, i took like four cups of that stuff
by AllRighh February 15, 2008
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The potent concoction of Rohypnol and Mountain Dew. Commonly used in southern states to knock fellow ancestors unconscious.
“Hey Sam cook me up some more Alabama NyQuil! I think Sister Sarah is waking up!”
by Bobby Windchime May 4, 2019
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Instead of swallowing an ambien for sleep, you crush it into a nice powdery line and snort it for instant effect.
Guy 1: Hey man I have to go to sleep like right now. I have to be up at 6 for work.

Guy 2: Do you want a shot of whiskey to fall asleep faster?
Guy 1: I’m way ahead of ya. I’m taking a Colombian NyQuil . Be out in a minute
by Les Carroll September 1, 2020
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It’s chicken cooked with NyQuil it’s truly delicious.
“That NyQuil chicken I had yesterday was fucking bomb
by ZachDoYouKnowCandice? October 24, 2019
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