A playful way of saying no.
tyler: are you drunk or something?
jed: nopes.
by sfjedi January 7, 2009
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The ultimate vocal response in Team Fortress 2, spoken by the Engineer. A single word so powerful that not even the greatest RAGE or trolling can counter its effects.
1)
Player A: We'd probably be winning if we didnt have 5 engies building shit at the spawn

Engineer: NOPE

2)
Disgruntled player A: RTV! NOMINATE! SCRAMBLE! This map sux111!! Youre all using HAX!!11!

Engineer: NOPE
by Zeromus255 October 4, 2011
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-To deny your ability to perform physical activities
-to bail out
-to fail
Boy1:OK, Brady you can do this back flip!
Brady: Well, okay...Okay guys!
Boy2:DO IT BRADSTAAAAAAH!!!! I'm filming!!!
Brady: I can do it!
*halfway through back flip*
Nope!
*falls on neck*
All: *hysterical laughter*
by 13333333337gangsta February 23, 2009
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The new generations response to drug use. NOPE to DOPE. Showing an attitude of being disgusted with dope does. It's owning better choices for yourself.
NOPE! Noway I would poison myself with drugs!
by jesRika December 26, 2019
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slang for "no"
After hearing him say sorry for being a lamer about screwing with my best friend and ditching her, I said, "NOPE, she's never gonna talk to you since you flat out rejected her AND stopped talking to her!"
by wiCkEd eEv January 23, 2003
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The most common response from women when a man asks for anal sex.
Man: Would you like to try something?
Woman: Sure. Sounds exciting.
Man: Can we try anal? I'll be gentle...
Woman: Nope.
by Andy Mui November 7, 2011
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Not happening. Nah. No no. NOT going to happen. I SAID NO! Nope.
by Pieceofshit43 May 6, 2020
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