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a flat-out refusal; the complete and ultimate rejection of reality and all things associated with said reality.
Teacher: your assignment for tomorrow's class is a three-paged reflection on a motif of the twenty paged short story, which I am handing out to you now. Now, clear off your desks for the pop quiz. Oh and don't forget, the test two days from now is on the entire semester's worth of material, forgot to mention that.
Jessica: Nope.
by human sacrifice dept. [R.INC.] April 02, 2009
27 1
A word to express when you know what you are attempting will not be successful.
Man 1:Hey dude do a backflip!

Brady: *attempts backflip* nope! *lands on neck*
by Cdawgie October 25, 2008
61 37
-To deny your ability to perform physical activities
-to bail out
-to fail
Boy1:OK, Brady you can do this back flip!
Brady: Well, okay...Okay guys!
Boy2:DO IT BRADSTAAAAAAH!!!! I'm filming!!!
Brady: I can do it!
*halfway through back flip*
*falls on neck*
All: *hysterical laughter*
by 13333333337gangsta February 23, 2009
90 70
A nope is

1) a sinonym for spiders,insects,snakes and everything that's creepy as hell. They live in Nopeland,a swampy area of the LandIwillNeverVisit.
2) a reaction for spiders,insects,snakes and everything that's creepy as hell.
*goes out*
*sees a nope*
*runs home shouting: nope,nope,nope!*
by dgnoengr May 09, 2014
7 0
A playful way of saying no.
tyler: are you drunk or something?
jed: nopes.
by sfjedi January 06, 2009
8 1
The ultimate vocal response in Team Fortress 2, spoken by the Engineer. A single word so powerful that not even the greatest RAGE or trolling can counter its effects.
Player A: We'd probably be winning if we didnt have 5 engies building shit at the spawn

Engineer: NOPE

Disgruntled player A: RTV! NOMINATE! SCRAMBLE! This map sux111!! Youre all using HAX!!11!

Engineer: NOPE
by Zeromus255 October 03, 2011
24 19
The most common response from women when a man asks for anal sex.
Man: Would you like to try something?
Woman: Sure. Sounds exciting.
Man: Can we try anal? I'll be gentle...
Woman: Nope.
by Andy Mui November 06, 2011
9 9