Generic term describing the pain/blister on your thumb from playing long sessions of video games.
After playing the new Mortal Kombat game for 12 hours straight, John had a seriously bad case of Nintendo Thumb.
A condition marked by blisters, which come after a long session of playing a video game. So named because the NES
Controllers caused this condition frequently.
I beat Renegade, and all I have to show for it is a bad case of Nintendo thumb.
The numbness of the thumbs and index fingers commonly occurring after hours of game console use.
"Those fucking Covenant sonofabitches are giving me nintendo thumb!"