A condition marked by blisters, which come after a long session of playing a video game. So named because the NES Controllers caused this condition frequently.
I beat Renegade, and all I have to show for it is a bad case of Nintendo thumb.
by Wadatah May 21, 2005
Generic term describing the pain/blister on your thumb from playing long sessions of video games.
After playing the new Mortal Kombat game for 12 hours straight, John had a seriously bad case of Nintendo Thumb.
by Apocalyptimaniac September 24, 2005