An expression used when somebody says/writes something so utterly stupid or banal it actually makes your brain hurt.
"I love blinking, I do."

"ZOMG, you're stepping on my brain!"
by Tramned October 10, 2009
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A phrase used to express great disbelief, shock, excitement, surprise or any heightened emotions.
"Bro, these Jordans are so fucking mad!! BURST MY HEAD/ BRAINS"
by cAsted November 8, 2017
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The Famous Words Of Homer Simpson. Also refers to a drunken man or woman who has hurt their Frontal lobe section. Or stuck a crayon up their nose and hit their brain.
"Dope! I think I brained my damage" "Hunny, My damage is brain"
by Fat Ass-Jenny May 22, 2008
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A description of what remains of one’s mind after slogging through excessive work, living on low sleep or poor nutrition, or dealing other people’s bullshit.
Wow, I did nothing but grind on schoolwork from August to December. My last two brain cells are going to play some Minecraft.

My last two brain cells are running on Chicken McNuggets for breakfast and 3 hours of sleep, so I probably won’t be able to finish the report by the deadline.

My boss whines every day about how lazy I am, even though I work 80 hours a week. My last two brain cells are not cut out for this shit.
by WeAlsoDoSomeTrolling October 28, 2022
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When you go too school and they ask you " what is 3x*9g/7^r.33333333333333333333" then goes over to your desk and says "HURRY UP LARRY THE ANSWER IS DO AT THE END OF CLASS"
Teacher: " what is 3x*9g/7^r.33333333333333333333"

You: Shut up, my one brain cell is working very hard right now!!!
by greencreeper244 March 20, 2018
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1. Something so crazy/insane that you can’t even

2. Something that makes you think ; makes your brain work
1. Person 1- *sends meme of girl acting weird*

Person 2- “That ran my brain

2. Person 1- *sends fun fact*
Person 2- “That ran my brain”
by randomsubs123 February 4, 2018
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A more aggressive, in-depth, informative approach to picking ones brain for information.
Adjective: "Hey Steve, I know you really want to come work at the company I'm at. Want to eat my brain about it over drinks later? "
by @black_forests April 27, 2017
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