The coolest and nicest city in the world located in Antioquia, Colombia.
person 1: I wanna go to Medellin
person 2: i know man that shit is awesome
person 1: ya not like Bogota or those other Colombian cities
person 2: Medellin is da best!
by Metalhead696 October 9, 2008
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Medellin also a large city in Colombia, used when referring to hard, or addicting. Much like cocaine and "bricks" of the substance.
I'm 100% Medellin baybay.

170lbs of Medellin hoe

That sh*t is medellin man.
by robtheman September 26, 2011
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During the 1980s, Pablo Escobar became known internationally as the Medellin Cartel gained notoriety. The Medellín Cartel is said to have controlled roughly eighty percent of the shipments that entered into the United States, Mexico, Puerto Rico, and the Dominican Republic with shipments brought mostly from Peru and Bolivia, as Colombian coca was initially of substandard quality. Escobar's product reached many other nations, mostly around the Americas, although it is said that his network reached as far as Asia.
Escobar bribed countless Colombian government officials, judges and other politicians, and he often personally executed uncooperative subordinates and had anyone he viewed as a threat assassinated, resulting in the deaths of hundreds of individuals. Corruption and intimidation characterized the Colombian system during Escobar's heyday. He had an effective, inescapable strategy that was referred to as plata o plomo; Spanish for "silver or lead", intended to mean "accept a bribe or face assassination." Escobar was also responsible for the killing of three Colombian presidential candidates who were all competing in the same election, as well as the bombing of Avianca Flight 203 and a Bogotá security building in 1989. The Medellin Cartel was also involved in a deadly war with its main rival, the Cali Cartel, for most of its existence.
by Dancing with Fire July 9, 2011
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the medellin cartel was a cartel fromed by pablo escobar in colombia around the 1970s it is very famous in many movies and in the one game gta 3. in theyr later years they controlled over 80% of all worldwide drug trade and pablo escobar was classified as one of the worlds richest man. he even declared war on colombias judicial system leaving many dead. he died when he compromised to pay colombias external debt to the united states and they sent the dea to find and kill him.
gta 3, scarface, and a whole lote of other movies and games i cant remember (medellin cartel)
by gunzt3r lopez November 17, 2007
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The act of receiving antibodies or immunity in general by eating out a women’s vagina and ingesting her vaginal juices which may contain antibodies to various viruses or bacteria.
“Juan, why didn’t you get the COVID vaccine?” “Nah man, I Got a Medellin transfusion last week I’m good.”
by Schmohawk1 April 24, 2021
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The Medellin Effect is when producers/directors cut an incredible trailer to mask a terrible movie. The excitement generated by the excellent trailer is directly correlated with how shitty the movie will eventually be. Originally made famous from the HBO show "Entourage."
I'll admit that footage does look good. That being said, this might be another prime example of the Medellin effect.
by ISolveProblems1985 July 24, 2016
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When you’ve done a bunch of blow, you get up a good thick loogey, and spit it on your partner’s asshole before you fuck it. Lube + numbing agent. Alternatively called The Colombian Mung Bean.
We were so horny and so high on coke, I figured I might as well give her the Medellin Mung Bean so we could really turn the heat up with some anal sex.
by Lucky Pierre 2022 August 4, 2022
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