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1.
The coolest and nicest city in the world located in Antioquia, Colombia.
person 1: I wanna go to Medellin
person 2: i know man that shit is awesome
person 1: ya not like Bogota or those other Colombian cities
person 2: Medellin is da best!
by Metalhead696 October 08, 2008
 
2.
Medellin also a large city in Colombia, used when referring to hard, or addicting. Much like cocaine and "bricks" of the substance.
I'm 100% Medellin baybay.

170lbs of Medellin hoe

That sh*t is medellin man.
by robtheman September 26, 2011